Pharmacological Targeting of PI3 Kinase Delta in B-Cell Driven Autoimmune Diseases

Time: 9:10 am
day: Day Two


  • Explain the biological relevance of targeting PI3 kinase (PI3K)delta in B-cell driven autoimmunity
  • Outline the drug discovery story of Parsaclisib (INCB050465), a highly selective small molecule PI3Kdelta inhibitor
  • Describe the key biochemical, cellular and preclinical model data that supported clinical trials with Parsaclisib (INCB050465) in autoimmune indications