Aimee Payne

Aimee Payne

Company: University of Pennsylvania

Job title: Professor & Co-Founder of Cabaletta Bio


Dr. Payne is a Professor of Dermatology and Director of the Clinical Autoimmunity Center of Excellence at the University of Pennsylvania.  Her clinical practice focuses on autoimmune skin diseases, with particular focus on the autoimmune blistering disease pemphigus vulgarisDr. Payne’s laboratory research has focused on understanding how B cell autoimmunity occurs in pemphigus in order to develop precision medicine therapies for disease.  Her laboratory pioneered a novel chimeric autoantibody receptor (CAAR) T cell technology for targeted depletion of autoreactive B cells, which is now advancing to clinical trials for mucosal pemphigus vulgaris.  Outside of Penn, Dr. Payne serves on the Medical Advisory Council of the International Pemphigus and Pemphigoid Foundation, the NIAMS Board of Scientific Counselors, and is co-founder and co-chair of the Scientific Advisory Board at Cabaletta Bio, Inc., focused on targeted cellular immunotherapy of B cell-mediated diseases. 


Live Q&A 4:50 pm

Using this opportunity to ask your expert speakers those burning questions.Read more

day: Day One

CAAR T Cells: Precision Cellular Therapeutics for Antigen-Specific B Cell Depletion 3:50 pm

Chimeric autoantibody receptors (CAARs) direct potent and specific T cell killing of autoantigen-specific B cells Specific elimination of pathogenic B cells with sparing of normal B cells may lead to long-term remission of B cell-mediated autoimmune disease without the risks of generalized immunosuppression CAAR T cell therapeutics are under investigation for pemphigus vulgaris, myasthenia gravis,…Read more

day: Day One

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